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ハワイアンウッドローズ種子抽出液の雄マウスの行動及び神経症状に及ぼす影響
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福森信隆、安藤 弘、久保喜一、湯澤勝廣、長澤明道、高橋 博、矢野範男、不破 達、大橋則雄、小縣昭夫
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東京都健康安全研究センター
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Effects on the Behavior and Neural Symptoms of Male Mice Administrated Extract of Commercially Distributed Hawaiian Wood Rose Seed
Nobutaka FUKUMORI Hiroshi ANDO Yoshikazu KUBO Katsuhiro YUZAWA Akemichi NAGASAWA Hiroshi TAKAHASHI Norio YANO Tatsu FUWA Norio OHASHI Akio OGATA
The Tokyo Metropolitan Government enacted an ordinance on illegal drug abuse prevention. As a result plant-derived drugs rather than chemical drugs have been dominating the market. Extract of commercially distributed Hawaiian wood rose seed containing lysergic acid alkaloids was administered by gavage to mice and the neuro-behavior of these animals was observed using the screening method that has been developed in our laboratory. In the high dose group head twitching sedation increased sound response and reinforcement of pain response and tendon reflex were observed. These results suggest that an alteration in the serotonin level in the brain is involved in these changes.
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| Keywords: |
ハワイアンウッドローズ種子抽出液 , スクリーニング試験 , 行動 , 神経症状 , 雄マウス , |
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[PDF (354.2K)]
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第6巻 , 第1号 , (pp.58-65)
