|
無承認無許可医薬品中の抱水クロラールの分析
|
|
鈴木 仁、高橋美佐子、長嶋真知子、瀬戸隆子、森謙一郎、荻野周三
|
|
東京都健康安全研究センター
|
Determination of Chloral Hydrate in Unapproved/Unpermitted Drugs
Jin SUZUKI Misako TAKAHASHI Machiko NAGASHIMA Takako SETO Ken'ichiro MORI and Shuzo OGINO
Tokyo Metropolitan Institute of Public Health
An analysis method to detect chloral hydrate in unapproved/unpermitted drugs was developed. In the qualitative method chloral hydrate was extracted with dichloromethane and then analyzed with gas chromatography-mass spectrometry and thin layer chromatography. The reagent of 24-dinitrophenylhydrazine was used for staining in with thin layer chromatography. In the quantitative method chloral hydrate was extracted with diisopropyl ether and then analyzed with gas chromatography-mass spectrometry using an internal standard 123-trichloropropane. A total of 5.7w/w% of chloral hydrate was detected from the liquid sample displayed to used the Spanish fly as raw material.
|
| Keywords: |
抱水クロラール , 無承認無許可医薬品 , 薄層クロマトグラフィー , 質量分析計付ガスクロマトグラフィー , 24-ジニトロフェニルヒドラジン , |
|
|
[PDF (436.8K)]
|
|
第6巻 , 第1号 , (pp.43-50)
