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メチレンジオキシ・ピロバレロンの中枢神経作用－マイクロダイアリシス法を用いて－
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不破達１、児玉亨２、本多芳子２、田中豊人１、久保喜一１、大橋則雄１、中江大１、小縣昭夫１
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１東京都健康安全研究センター ２東京都神経科学総合研究所
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Influence of Methylenedioxypyrovalerone on Central Nervous System -Using Microdialysis Method-
Tatsu FUWA１ Tohru KODAMA２ Yoshiko HONDA２Toyohito TANAKA１ Yoshikazu KUBO１ Norio OHASHI１ Dai NAKAE１ Akio OGATA１
１Tokyo Metropolitan Institute of Public Health.
２Tokyo Metropolitan Institute for Neuroscience.
Extracellular levels of dopamine (DA) and serotonin (5-HT) were assayed in striatum of freely moving mice using microdialysis and high performance liquid chromatography with electrochemical detection (HPLC-EC) following oral administration of methylenedioxypyrovalerone (MDPV). As well as these experiment we performed the measurement of locomotor and behavior activities and examined whether central nerve injury was caused by repetitive administration using an immunohistochemical method. Dialysates were assayed at 10 minute intervals until 2.5 hours after an oral administration of MDPV. DA extracellular content was 210% of control at 0-30minutes and 208% at 30-60 minutes. But 5-HT was not significantly influenced by MDPV administration. Increasing of the DA level was more moderate by MDPV than other amphetamine like stimulants; methamphetamine and MDMA. It was thought that the augmentation of locomotor and behavior activities increased when dopamine content became more than 200% of the control level in striatum. The neurotoxicity of MDPV was not observed in this experiment.
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マイクロダイアリシス , ドーパミン , メチレンジオキシ・ピロバレン , 線条体 , |
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[PDF (393K)]
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第5巻 , 第1号 , (pp.62-71)
