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ICRマウスにおける難燃剤テトラブロモビスフェノールA 2週間投与の影響
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多田幸恵1、藤谷知子1、小縣昭夫１、上村尚２
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1東京都健康安全研究センター環境保健部生体影響研究科、2退職
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The effect of two weeks administration of tetrabromobisphenol A a flame retardant in ICR mice
Yukie TADA1 Tomoko FUJITANI Akio OGATA Hisashi KAMIMURA
Tetrabromobisphenol A (TBBPA) is widely used as a flame retardant and detected in air at the dismantling plant sewage sludge sediment or human serum samples. In the present study we examined effects of TBBPA on the liver when administered to mice for fourteen consecutive days. Crlj:CD1(ICR) male mice (7 weeks old) were given 0 (control) 350 700 or 1400 mg/kg body weight/day TBBPA (99.1% pure) in olive oil for 14 days. Serum concentration of total-cholesterol in the high dose (1400 mg/kg BW) group was higher than that of the control group. Absolute and relative liver weights were dose-dependently increased and significantly higher in the high dose group than the control group. Histological findings showed that slight enlargement of hepatocytes inflammatory cell infiltration and focal necrosis of hepatocytes were more marked in the liver of the treated groups than in the control group. Generally it has been accepted that TBBPA has no critical toxicity for major organs including the liver and kidney in young and adult rats or mice. However the present data indicate possible hepatotoxicity of TBBPA in ICR male mice.
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| Keywords: |
テトラブロモビスフェノールA , 難燃剤 , マウス , 肝臓 , 脂質代謝 , |
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[PDF (240.2K)]
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第4巻 , 第1号 , (pp.60-68)
