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佐々木研究所における化学物質のリスク評価・管理に資する毒性病理学的研究．（１）コリン欠乏アミノ酸食投与ラット肝発がんモデルによる知見
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中江 大
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財団法人佐々木研究所病理部
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Articles in this special program of the journal describe the significance of the risk assessment/management for the assurance and maintenance of human health and welfare and the importance of toxicologic pathology in such an attempt. The Sasaki Institute (Department of Pathology) has been contributing to the risk assessment/management of chemicals by doing researches on the detection of toxicity/carcinogenicity of chemicals the elucidation of its underlying mechanisms and the influence of chemicals toward particular pathological situations (e.g. carcinogenesis) using animal models extrapolative to the human situations. Among them this article introduces findings from researches on a hepatocarcinogenic model of rats fed a choline-deficient L-amino acid-defined diet.
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Sasaki Institute , toxicologic pathology , risk assessment/management of chemicals , dietary choline deficiency , hepatocarcinogenesis , |
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[PDF (1264.5K)]
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第1巻 , 第3号 , (pp.331-352)
