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OECD HPV/SIDS点検プログラムを通じての国際貢献
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蛭川 舞・星野歳三・美濃部安史、Ulrich Maurer、Marcel Ceresiat、望月次郎・村田 収
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財団法人 化学物質評価研究機構、Clariant GmbH、Tessenderlo Chemie NV/SA、イハラケミカル工業株式会社
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The international contribution through an OECD HPV/SIDS program
Mai Hirukawa1 Toshimitsu Hoshino1 Yasushi Minobe1
Ulrich Maurer2 Marcel Ceresiat3 Jiro Mochizuki4 Osamu Murata4
1Chemical Evaluation and Research Institute Japan (CERI) 2Clariant GmbH
3Tessenderlo Chemie NV/SA 4Ihara Chemical Industry Co. Ltd.
Abstract: Through a 1990 OECD Council Decision Member countries decided to undertake the investigation of high production volume (HPV) chemicals in a co-operative way. These HPV chemicals include all chemicals reported to be produced or imported at levels greater than 1000 tonnes per year in at least one Member country or in the European Union region. The overall objective of the HPV Chemicals Programme is to co-operatively undertake an initial assessment of HPV chemicals to screen them and agree on the need for further work. Member countries co-operatively investigate HPV chemicals in order to identify those which are potentially hazardous to the environment and/or to the health of the general public or workers.
Member countries share the burden of this investigation and acquire data elements needed for "screening" HPV chemicals. The data elements were agreed in OECD and called the Screening Information Data Set or SIDS. When existing data are determined to be inadequate to support the requirements for SIDS element additional tests are required in principle. SIDS documents (SIDS dossier including the robust study summaries SIDS Initial Assessment Report; SIAR SIDS Initial Assessment Profile; SIAP) are prepared based on the information collected. These documents are reviewed by the Sponsor country. And at the SIDS Initial Assessment Meeting (SIAM) the documents are discussed and consensus reached on the initial hazard assessment. This process results in an internationally agreed assessment for each chemical with agreed conclusions and recommendations. Finally when the SIDS documents are finalized these are made available worldwide through UNEP chemicals. From 1998 OECD work on HPV/SIDS program has been accelerated by the International Council of Chemical Associations (ICCA) HPV Initiative. ICCA HPV Initiative is voluntary action by the global chemical industry to speed up the process of OECD HPV/SIDS program.
The authors built the international collaborative alliance for sharing the work to participate in the work for OECD HPV/SIDS program toward SIAM17 2003. Ihara Chemical Industry Co. Ltd. the lead company Clariant GmbH (Germany) and Tessenderlo Chemie NV/SA (Belgium) took part in this consortium to share the burden and CERI Chemicals Evaluation and Research Institute Japan supported them to make the assessment documents. Our target chemical is 1-chloro-2-(chloromethyl) benzene (o-chlorobenzyl chloride; OCBC). OCBC is used only as intermediate for the production of agrochemicals. Annual production volume of OCBC in Japan has been decreasing to a few hundred tones recently production in Belgium and Germany was in the same range. As a consequence of our investigation however it was evident that OCBC possesses properties indicating a hazard for human health and the environment. And because considerable hydrolysis of OCBC is anticipated it was necessary to take into consideration the aquatic effect of its hydrolysis product. Furthermore detailed exposure information was required. We collected information regarding the exposure in OCBC manufacturing plants and paid attention to describe about the point clearly in relation to the hazardous profile of OCBC.
The draft SIDS documents have been forwarded to the ICCA committee for further comments. Stakeholders from many countries requested additional information on intrinsic properties and exposure situation. The consortium discussed hazard and exposure assessment and formulated a final set of documents which have been presented by the sponsor country at SIAM17. And it was concluded from existing data that “OCBC possesses properties indicating a hazard for human health and the environment. Based on data presented by the Sponsor country exposure to humans and the environment is anticipated to be low and therefore OCBC is currently of low priority for further work. Countries may desire to investigate any exposure scenarios that were not presented by Sponsor countries.” Thanks to giving us the opportunity to present these documents the final revision manuscripts submitted to OECD is introduced below.
(ChemoBio Integrated Management 1(1):105-117 2005)
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| Keywords: |
HPV , High Production Volume , SIDS , OCBC , |
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[PDF (816.5K)]
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第1巻 , 創刊号 , (pp.105-117)
